I came across a situation where an organization had been setup to use RPC/HTTPs “Outlook Anywhere” for some time and all the Outlook 2003 clients seemed to work fine. One user had Outlook 2007 and was unable to connect using this method. In the LAN and through OWA everything worked fine. I tried tons of different solutions online but in the end, the problem was with the configuration in Exchange. I looked over the suggested configuration here:

http://www.petri.co.il/configure_rpc_over_https_on_a_single_server.htm

and I discovered that the RPC ports hadn’t been configured as the article suggests. I used the recommended “RPCnofrontend” tool: http://www.petri.co.il/software/rpcnofrontend.zip and everything worked fine after that.

The issue:
Unable to open a file directly on the desktop or in explorer using double-click or right-click->Open.

Quick fix:
For example, to repair Excel’s file extension (.xls) type the following in Start –> Run…
“C:\Program Files\Microsoft Office\Office\Excel.exe” /Regserver

There is no specific SMTP service like you saw with Exchange 2003 and IIS. However, if you’re just trying to stop the listening port 25 for Inbound/Outbound mail, stop the ‘Microsoft Exchange Transport’ service.